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Thread: Hormones and Redox Signaling Molecules?

  1. #1
    ASEA Power Team Member Aaron Murakami's Avatar
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    Hormones and Redox Signaling Molecules?

    Quote Originally Posted by FRC View Post
    Taking six grams of glycine will make your body release more HGH (human growth
    hormone) and this is beneficial in older people-after thirty. The way the testamonials sound for Redox Signaling Molecules, something similar is happening. Or the amount of HGH that is being normally released is being utilized by the body much better. I would like to hear more about this and its
    relationship to HGH. Also Redox Signaling Molecules relationship to the sex
    hormones- testosterone, progesterone, etc. Has any study been done where
    blood test levels of these hormones were taken before taking Redox Signaling Molecules, and levels compared, after taking Redox Signaling Molecules for a
    period of time, say three months for example?
    I used to deal with the best HGH on the market years ago - Regenesis Pro 500. There were a lot of women that had reached menopause that actually started to have their periods again. Not that that was desirable for them but it certainly told a story. Of course it is better to get our own body to make more.

    However, with HGH or any other compound we're giving the body or having the body stimulate on its own, the effectiveness of it will always be proportionate to the body's cell to cell communication efficiency.

    A baby has 100% cellular efficiency - someone at 70 has 10% cellular efficiency. This is something that no other supplement can address. The closest would be a supplement that boosts ATP production like LJ100 (tongkat ali), creatine and ribose, etc... since there is a corresponding increase in redox signaling molecules produced simultaneously with ATP. But there is a finite amount of this that can be produced by our body and as we age there is a continuous decline in the number of mitochondria that produces the atp/redox signaling molecules to begin with.

    The redox signaling molecules are what the cells use for the communication and when drinking these balanced redox signaling molecules, increase that cellular communication ability back to when were were much younger.

    Now the mitochondria are more susceptible to oxidative stress than most other cells. By the time some one is 90 years old, 95% of their mitochondria are damaged.

    There are some compounds that have been found to be able to help repair some of those mitochondria and even get them to replicate new mitochondria! They're the only cells in the body that have their own DNA.

    These compounds that can stimulate new mitochondria are ultra powerful antioxidants and hold up to oxidation way more powerfully than Vitamin C, etc...

    But with the stimulation of glutathione, sod and catalase, there is no stronger antioxidant/enzyme combo that can outdo this - especially when not only the quantity of them are increased but the effectiveness is increased by HUNDREDS of % - this is made possible by giving the body the balanced redox signaling molecules.

    I hope to see more studies on this product specifically in regards to the stimulation of new mitochondria production. Theoretically, perpetually extending the length of the telomeres and having enough mitochondria to create enough atp and redox signaling molecules, someone could literally live forever.

    I do not know of studies between the redox signaling molecules and hormones. But I will ask the atomic physicist that stabilized this product when he comes to Spokane for a medical symposium next month.
    Blessings,
    Aaron Murakami
    ASEA Advancing Life

  2. #2
    Every day ASEA causes a stronger hormonal response I can feel. I can't say about growth hormone, which would be ideal too, but as a 59 yr-old male I appreciate the testosterone and perhaps endorphin release. It's like a boomerang that just hits me all of a sudden, and more than 17 or 120 minutes from taking ASEA. I could almost elbow the crack dealers aside but not quite since people would have to sit and wait or take a nap before natural effects would come into play. I don't think they'd have the patience.

    Then there is the prostate and its inflammation and "bad" testosterone, where ASEA might help too, both at level of inflammation and fundamentally by rejuvenating the relevent tissues.

  3. #3
    I liked 6 OXO. 6 OXO Lowest price | Reviews and Side Effects
    Its discontinued, due to substance controllers who decide what items can go in your mouth. I'll look into similarities with tongkat ali.

    Chrysalis was a HGH replica, I procured twice. Then Slave Masters prohibited it, as feed additive for lower level humans.
    Chrysalis Nutritionist Stephen Heuer Arrested by Federal Marshalls in FDA Raid

  4. #4
    "There are some compounds that have been found to be able to help repair some of those mitochondria and even get them to replicate new mitochondria! They're the only cells in the body that have their own DNA...These compounds that can stimulate new mitochondria are ultra powerful antioxidants and hold up to oxidation way more powerfully than Vitamin C, etc...But with the stimulation of glutathione, sod and catalase, there is no stronger antioxidant/enzyme combo that can outdo this - especially when not only the quantity of them are increased but the effectiveness is increased by HUNDREDS of % - this is made possible by giving the body the balanced redox signaling molecules...I hope to see more studies on this product specifically in regards to the stimulation of new mitochondria production. Theoretically, perpetually extending the length of the telomeres and having enough mitochondria to create enough atp and redox signaling molecules, someone could literally live forever."

    There's a telemere length preserving supplement which will be affordable to most people. I will have an update soon.

    HGH, insulin, testosterone, need to balance the three to live well and longer.

  5. #5
    Quote Originally Posted by BobDodds View Post
    "There are some compounds that have been found to be able to help repair some of those mitochondria and even get them to replicate new mitochondria! They're the only cells in the body that have their own DNA...These compounds that can stimulate new mitochondria are ultra powerful antioxidants and hold up to oxidation way more powerfully than Vitamin C, etc...But with the stimulation of glutathione, sod and catalase, there is no stronger antioxidant/enzyme combo that can outdo this - especially when not only the quantity of them are increased but the effectiveness is increased by HUNDREDS of % - this is made possible by giving the body the balanced redox signaling molecules...I hope to see more studies on this product specifically in regards to the stimulation of new mitochondria production. Theoretically, perpetually extending the length of the telomeres and having enough mitochondria to create enough atp and redox signaling molecules, someone could literally live forever."

    There's a telemere length preserving supplement which will be affordable to most people. I will have an update soon.

    HGH, insulin, testosterone, need to balance the three to live well and longer.
    I am also interested in anti-aging research. This is the email that I sent.

    "I just got though listening to the Redox presentation, and my biggest
    question concerns the relationship between RSM and telomerase. I have
    been keeping up with the latest on anti-aging research, and this is
    the first time hearing about RSM. The latest research on telemeres is
    profound. However, the procedure/product out of this research is very
    expensive. The research is that as we age, we produce less telemerase,
    which is an enzyme used to keep telemeres healthy and long. As the
    telemers shorten, eventually our cells quit dividing and we age. That
    is a basic explanation, I know. But where does this research fit in?
    If you know or can find out, I would very much appreciate it and then
    decide to take and market the product."

    So, it sounds like you may know something about this.
    Last edited by lsjimm; 10-16-2011 at 06:11 PM.

  6. #6
    Thanks a lot for giving this information..very helpful.

  7. #7
    I looked into this Bob. Very interesting:

    A 90-year-old man typically contains 95% damaged mitochondria, compared to almost no damage in that of a 5-year-old. Cancer is fundamentally connected to mitochondrial dysfunction. Dysfunctional mitochondria deny cells the ability to go through normal apoptotic removal processes. Mitochondria make up an astonishing one-third of the mass of the human heart. Mitochondrial density is 38% lower in the offspring of diabetic parents.

    Exercise activates the AMPK pathway and the role of PGC-1alpha (peroxisome-proliferator-activated receptor gamma co-activator-1alpha) as a co-transcriptional regulation factor that induces mitochondrial biogenesis by activating transcription factors.

    We could protect and improve the function of existing mitochondria using nutrients like L-carnitine, lipoic acid, and coenzyme Q10. ALCAR and Alpha-Lipoic acid are beneficial in restoring mitochondrial function.

    After treatment with hydergine, it can be seen that the total mitochondrial volume of old rats was nearly the same as the young rats. Furthermore, the mitochondrial size was altered to a more youthful direction.

    Now PQQ (Pyrroloquinoline Quinone) is the First New Vitamin discovered since 1948.
    Found in common foods, good sources of PQQ being parsley, green tea, tofu, tomatoes green peppers, kiwi fruit and papaya. Mice/rats fed diets lacking PQQ have reduced mitochondrial content.

    Research indicated PQQ actually allowed mitochondria to multiply.
    One case presentation with muscle biopsy showed after 3 months of supplementation, the muscle cells had about 20 times the mitochondria they had before supplementation.

    PQQ increased citrate synthase and cytochrome c oxidase activity, Mitotracker staining, mitochondrial DNA content, and cellular oxygen respiration.

    PQQ triggers aging cells to grow new mitochondria. This process, called mitochondrial biogenesis, can prevent age-related cell death that accelerates brain degeneration. The most notable ways in which PQQ protects the brain from aging are related to its powerful redox cycling abilities. By far its the most robust of the redox cyclers available. PQQ potently blunts the deadly effects of reactive oxygen species (ROS).

    PQQ may induce mitochondrial biogenesis through a mitochondrial-related cell signaling mechanism.

    PQQ also stimulates natural production of nerve growth factor (NGF) which triggers growth and branching of nerve cells. In one study, a one-centimeter gap in the sciatic nerve underwent rapid healing after treatment with PQQ, demonstrating improved nerve conduction velocity, strength of the nerve impulse, and increased numbers of nerve cells inside the sheath.

    PQQ also diminishes the impact of excitotoxicity.
    PQQ’s powerful redox cycling abilities help it to chemically modify receptors for the most potent excitotoxic neurotransmitter, known as NMDA (N-Methyl-D-aspartic acid). Under the influence of PQQ, the NMDA receptors literally “quiet down” and stop producing the toxic effects that lead to neuronal dysfunction. In related actions, PQQ protects against environmental neurotoxicity as well, as in the case of deadly mercury poisoning.

    Uranium is so toxic because it binds to PQQ and prevents its biological actions.

    PQQ protects neurons against glutamate-induced cell damage by scavenging ROS, reducing Ca2+ influx, and caspase-3 activity. PQQ-activated PI3K/Akt signaling might be responsible for its neuroprotective action.

    PQQ-supplemented diet improves learning ability in healthy animals. PQQ suppresses spontaneous seizure activity and shortens duration of chemically induced seizures. PQQ achieves this effect without inhibiting normal NMDA receptor performance or baseline behavior.

    PQQ acts in living cells as a “redox cycler,” meaning that it modulates the flow of electrons that determine if a given chemical reaction produces oxidation or its opposite, known as reduction (hence “red-ox”). Redox cyclers are essential for protecting mitochondria from the vicious attacks (of ROS) generated during energy transfer activities.

    PQQ would appear to have therapeutic potential similar to resveratrol, genistein, hydroxytyrosol, quercetin, or other compounds that can induce mitochondrial biogenesis. Anti-diabetic drugs like metformin and thiazolidinediones also induce mitochondrial biogenesis

    PQQ is not the only dietary supplement that can activate PGC-1alpha and therefore unleash its chain of beneficial results including enhanced SIRT3 expression & mitochondrial biogenesis. Resveratrol, quercetin, rapamycin and other substances can also do this.

    Compounds that may promote mitochondriogenesis included resveratrol, quercetin, and hydroxytyrosol (found in olive oil). Other agents that promote mitochondrial function and performance may be synergistic. Such compounds include CoQ10 and carnitine.

    Many antioxidants, such as quercetin, green tea extracts, and vitamin C, are technically redox cyclers. But PQQ is tremendously more robust. A single PQQ molecule can undergo more than 20,000 cycles of oxidation/reduction before it is destroyed, while more conventional redox cyclers give out after at most about 800 cycles.

    Immune system cells rely heavily on adequate supplies of PQQ for normal function.

    Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.

    PQQ is a cofactor in a family of enzymes called quinoproteins. PQQ is a cofactor in PQQ-dependent dehydrogenase enzyme that is essential for the degradation of the amino acid lysine. This enzyme, also called lysyl oxidase, is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression.

    Generally, the faster the mitochondria turn over, the better. In other words, it is better to replace mitochondria before too much mtDNA damage accumulates. Calorie restriction speeds mitochondrial turnover (e.g., if calories are not used, less need). In contrast, exercise slows mitochondrial turnover and appears to promote mitochondriogenesis.

    Giving rats a supplement of pyrroloquinoline quinone that were previously fed diets devoid of PQQ, increases muscle and liver mitochondria about 10 to 20 percent somewhere between half a day to one and a half days.

    Sources:
    Reverse Brain Cell Death by Growing New Mitochondria

    Vitamin C Foundation - View topic - Grow new mitochondria

    PQQ – activator of PGC-1alpha, SIRT3 and mitochondrial biogenesis | AGING SCIENCES – Anti-Aging Firewalls

    http://pyrroloquinoline-quinone.com/pqq-info/

    You would have to eat 170 kg of natto, to get the same amount as a 10 mg supplement.
    Last edited by SocialCredit; 01-26-2012 at 07:12 AM.

  8. #8
    Hey...This information is very beneficial for me. I like this post.

  9. #9
    Is really a very good article. A great help to me. Now I want to go right to try. Thank you.

  10. #10
    Prodaja isključivo za Hrvatsku ASEA Redox signal molecule

    Ako imate bilo kakvih zdravstvenih problema a do sada niste naišli na učinkovitu terapiju istražite što je to ASEA i pokušajte zaključiti dali Vam može pomoći.
    Za sve informacije u vezi nabave proizvoda ASEA javite nam se na e-mail:

    redoxhrvatska@gmail.com

    Dostava na kućnu adresu.

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